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Article

Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X).

Cardiovascular research - 1 Dec 2004

Thomas Dierk, Hammerling Bettina C, Wimmer Anna-Britt, Wu Kezhong, Ficker Eckhard, Kuryshev Yuri A, Scherer Daniel, Kiehn Johann, Katus Hugo A, Schoels Wolfgang, Karle Christoph A

Abstract excerpt

OBJECTIVE: The human ether-a-go-go-related gene (hERG) encodes the rapid component of the cardiac repolarizing delayed rectifier potassium current, I(Kr). The direct interaction of the commonly used protein kinase C (PKC) inhibitor bisindolylmaleimide I (BIM I) with hERG, KvLQT1/minK, and I(Kr) currents was investigated in this study. METHODS: hERG and KvLQT1/minK channels were heterologously expressed in Xenopus...

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Identifiers

PMID: 15537500
DOI: 10.1016/j.cardiores.2004.07.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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