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Article

State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy.

American journal of physiology. Cell physiology - 1 Apr 2009

Ganapathi Sindura B, Kester Mark, Elmslie Keith S

Abstract excerpt

Human ether-a-go-go-related gene (HERG) potassium channel acts as a delayed rectifier in cardiac myocytes and is an important target for both pro- and antiarrhythmic drugs. Many drugs have been pulled from the market for unintended HERG block causing arrhythmias. Conversely, recent evidence has s...

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Source

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Identifiers

PMID: 19244476
DOI: 10.1152/ajpcell.00633.2008
PMCID: PMC2670659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19244476-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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