Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy.

American journal of physiology. Cell physiology - 1 Apr 2009

Ganapathi Sindura B, Kester Mark, Elmslie Keith S

Abstract excerpt

Human ether-a-go-go-related gene (HERG) potassium channel acts as a delayed rectifier in cardiac myocytes and is an important target for both pro- and antiarrhythmic drugs. Many drugs have been pulled from the market for unintended HERG block causing arrhythmias. Conversely, recent evidence has shown that HERG plays a role in cell proliferation and is overexpressed both in multiple tumor cell lines and in primary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arrhythmias, Cardiac
Share to Cyclin-Dependent Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to ERG1 Potassium Channel

Share to Ether-A-Go-Go Potassium Channels

Share to Ion Channel Gating

Share to Models, Cardiovascular

Share to Potassium Channel Blockers

Share to Purines

Source

Open in PubMed Open full text

Identifiers

PMID: 19244476
DOI: 10.1152/ajpcell.00633.2008
PMCID: PMC2670659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy.PMID 19244476Read ↗

Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X).Semantic proximity Read ↗

Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel.Semantic proximity Read ↗

Block of hERG channel by ziprasidone: biophysical properties and molecular determinants.Semantic proximity Read ↗

Discovery and development of Seliciclib. How systems biology approaches can lead to better drug performanceSemantic proximity Read ↗

Time is a critical factor in evaluating indirect hERG inhibition by Oligonucleotide TherapeuticsSemantic proximity Read ↗

Inhibition of cardiac HERG channels by grapefruit flavonoid naringenin: implications for the influence of dietary compounds on cardiac repolarisation.Semantic proximity Read ↗

Blockade of HERG K+ channel by an antihistamine drug brompheniramine requires the channel binding within the S6 residue Y652 and F656.Semantic proximity Read ↗

Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase.Semantic proximity Read ↗

Genistein and tyrphostin AG556 inhibit inwardly-rectifying Kir2.1 channels expressed in HEK 293 cells via protein tyrosine kinase inhibition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.