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Article

Molecular analysis of PIP2 regulation of HERG and IKr.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2004

Bian Jin-Song, Kagan Anna, McDonald Thomas V

Abstract excerpt

We previously reported that cloned human ether-a-go-go-related gene (HERG) K+ channels are regulated by changes in phosphatidylinositol 4,5-bisphosphate (PIP2) concentration. Here we investigated the molecular determinants of PIP2 interactions with HERG channel protein. To establish the molecular nature of the PIP2-HERG interaction, we examined a segment of the HERG COOH terminus with a high concentration of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocytes, Cardiac

Share to Patch-Clamp Techniques

Share to Phosphatidylinositol 4,5-Diphosphate

Share to Potassium Channels, Voltage-Gated

Share to Receptors, Adrenergic, alpha-1

Source

Identifiers

PMID: 15231497
DOI: 10.1152/ajpheart.00120.2004

Genes

ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular analysis of PIP2 regulation of HERG and IKr.PMID 15231497Read ↗

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