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Article

C5 deficiency and C5a or C5aR blockade protects against cerebral malaria

21 Apr 2008

Abstract excerpt

Experimental infection of mice with Plasmodium berghei ANKA (PbA) provides a powerful model to define genetic determinants that regulate the development of cerebral malaria (CM). Based on the hypothesis that excessive activation of the complement system may confer susceptibility to CM, we investigated the role of C5/C5a in the development of CM. We show a spectrum of susceptibility to PbA in a panel of inbred...

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PMID: 18426986
DOI: 10.1084/jem.20072248

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