Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA supercoiling and transcription control: a model from the study of suppression of the leu-500 mutation in Salmonella typhimurium topA- strains.

Progress in nucleic acid research and molecular biology - 1 Jan 2003

Wu Hai-Young, Fang Ming

Abstract excerpt

DNA supercoiling is known to modulate gene expression. The functional relationship between DNA supercoiling and transcription initiation has been established genetically and biochemically. The molecular mechanism whereby DNA supercoiling regulates gene expression remains unclear however. Quite commonly, the same gene responds to the same DNA supercoiling change differently when the gene is positioned at different...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes
Share to DNA Gyrase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Superhelical

Share to Escherichia coli Proteins

Share to Promoter Regions, Genetic

Share to Salmonella typhimurium

Share to Time Factors

Share to Transcription, Genetic

Source

Identifiers

PMID: 12882514
DOI: 10.1016/s0079-6603(03)01002-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA supercoiling and transcription control: a model from the study of suppression of the leu-500 mutation in Salmonella typhimurium topA- strains.PMID 12882514Read ↗

Suppression of leu-500 mutation in topA+ Salmonella typhimurium strains. The promoter relay at work.Semantic proximity Read ↗

Dependence of transcription-coupled DNA supercoiling on promoter strength in Escherichia coli topoisomerase I deficient strains.Semantic proximity Read ↗

Transcription-coupled hypernegative supercoiling of plasmid DNA by T7 RNA polymerase in Escherichia coli topoisomerase I-deficient strains.Semantic proximity Read ↗

Activation of the leu-500 promoter by adjacent transcription.Semantic proximity Read ↗

Local DNA topology and gene expression: the case of the leu-500 promoter.Semantic proximity Read ↗

Genomic transcriptional response to loss of chromosomal supercoiling in Escherichia coli.Semantic proximity Read ↗

R-loop-dependent hypernegative supercoiling in Escherichia coli topA mutants preferentially occurs at low temperatures and correlates with growth inhibition.Semantic proximity Read ↗

Control of RNA polymerase II promoter-proximal pausing by DNA supercoilingSemantic proximity Read ↗

DNA supercoiling and transcription: topological coupling of promoters.Semantic proximity Read ↗

Effects of RNA polymerase modifications on transcription-induced negative supercoiling and associated R-loop formation.Semantic proximity Read ↗

Rates of gyrase supercoiling and transcription elongation control supercoil density in a bacterial chromosome.Semantic proximity Read ↗

DNA twist, flexibility and transcription of the osmoregulated proU promoter of Salmonella typhimurium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.