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Article

Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells.

Molecular and cellular biology - 1 Aug 2003

Yamamoto Kazuhiko, Ishiai Masamichi, Matsushita Nobuko, Arakawa Hiroshi, Lamerdin Jane E, Buerstedde Jean-Marie, Tanimoto Mitsune, Harada Mine, Thompson Larry H, Takata Minoru

Abstract excerpt

The rare hereditary disorder Fanconi anemia (FA) is characterized by progressive bone marrow failure, congenital skeletal abnormality, elevated susceptibility to cancer, and cellular hypersensitivity to DNA cross-linking chemicals and sometimes other DNA-damaging agents. Molecular cloning identified six causative genes (FANCA, -C, -D2, -E, -F, and -G) encoding a multiprotein complex whose precise biochemical...

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Identifiers

PMID: 12861027
DOI: 10.1128/MCB.23.15.5421-5430.2003
PMCID: PMC165738

Genes

FANCG
BRCA2
BRCA1
FANCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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