Article
PKC eta regulates occludin phosphorylation and epithelial tight junction integrity.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2009
Suzuki Takuya, Elias Bertha C, Seth Ankur, Shen Le, Turner Jerrold R, Giorgianni Francesco, Desiderio Dominic, Guntaka Ramareddy, Rao Radhakrishna
Abstract excerpt
PKC eta is expressed predominantly in the epithelial tissues; however, its role in the regulation of epithelial tight junctions (TJs) is unknown. We present evidence that PKC eta phosphorylates occludin on threonine residues (T403 and T404) and plays a crucial role in the assembly and/or maintenance of TJs in Caco-2 and MDCK cell monolayers. Inhibition of PKC eta by specific pseudo substrate inhibitor or...
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