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Article

PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes.

Molecular cell - 2 Feb 2017

Ebner Michael, Lučić Iva, Leonard Thomas A, Yudushkin Ivan

Abstract excerpt

Protein kinase B/Akt regulates cellular metabolism, survival, and proliferation in response to hormones and growth factors. Hyperactivation of Akt is frequently observed in cancer, while Akt inactivation is associated with severe diabetes. Here, we investigated the molecular and cellular mechanisms that maintain Akt activity proportional to the activating stimulus. We show that binding of...

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Identifiers

PMID: 28157504
DOI: 10.1016/j.molcel.2016.12.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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