Article
Use of TP53 reference materials to validate mutations in clinical tissue specimens by single-strand conformational polymorphism analysis.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology - 1 Jan 2004
Sunar-Reeder Bulbin, Atha Donald H, Aydemir Songul, Reeder Dennis J, Tully Lois, Khan Abraham R, O'Connell Catherine D
Abstract excerpt
BACKGROUND: As genetic information moves from basic research laboratories in to the clinical testing environment, there is a critical need for reliable reference materials for the quality assurance of genetic tests. A panel of 12 plasmid clones containing wild-type or point mutations within exons 5-9 have been developed as reference materials for the detection of TP53 mutations. AIM: The goal of this study was to...
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