Article
Limitations of the use of single base changes in the p53 gene to detect minimal residual disease of breast cancer.
Molecular pathology : MP - 1 Jun 2002
Dang R K B, Anthony R S, Craig J I O, Leonard R C F, Parker A C
Abstract excerpt
BACKGROUND/AIMS: Peripheral blood progenitor cell (PBPC) transplantation is frequently used in the treatment of malignant diseases, but contamination of the graft by tumour cells is a real concern and may lead to disease relapse. The feasibility of applying heterogeneous single base genetic changes as tumour specific markers to detect minimal residual disease in PBPC harvests was studied, using the p53 gene and...
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