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Article

Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase.

Nucleic acids research - 1 Jan 2011

Chen Xin, Ma Jing-Jing, Tan Min, Yao Peng, Hu Qing-Hua, Eriani Gilbert, Wang En-Duo

Abstract excerpt

To prevent potential errors in protein synthesis, some aminoacyl-transfer RNA (tRNA) synthetases have evolved editing mechanisms to hydrolyze misactivated amino acids (pre-transfer editing) or misacylated tRNAs (post-transfer editing). Class Ia leucyl-tRNA synthetase (LeuRS) may misactivate various natural and non-protein amino acids and then mischarge tRNA(Leu). It is known that the fidelity of prokaryotic LeuRS...

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PMID: 20805241
DOI: 10.1093/nar/gkq763
PMCID: PMC3017609

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Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase.PMID 20805241Read ↗

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