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Article

Pyrrolysyl-tRNA synthetase variants reveal ancestral aminoacylation function.

FEBS letters - 1 Oct 2013

Ko Jae-hyeong, Wang Yane-Shih, Nakamura Akiyoshi, Guo Li-Tao, Söll Dieter, Umehara Takuya

Abstract excerpt

Pyrrolysyl-tRNA synthetase (PylRS) is a class IIc aminoacyl-tRNA synthetase that is related to phenylalanyl-tRNA synthetase (PheRS). Genetic selection provided PylRS variants with a broad range of specificity for diverse non-canonical amino acids (ncAAs). One variant is a specific phenylalanine-incorporating enzyme. Structural models of the PylRSamino acid complex show that the small pocket size and π-interaction...

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Identifiers

PMID: 23994531
DOI: 10.1016/j.febslet.2013.08.018
PMCID: PMC3778162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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