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Article

Viability of Escherichia coli topA mutants lacking DNA topoisomerase I.

The Journal of biological chemistry - 7 Jan 2005

Stupina Vera A, Wang James C

Abstract excerpt

The viability of the topA mutants lacking DNA topoisomerase I was thought to depend on the presence of compensatory mutations in Escherichia coli but not Salmonella typhimurium or Shigella flexneri. This apparent discrepancy in topA requirements in different bacteria prompted us to reexamine the topA requirements in E. coli. We find that E. coli strains bearing topA mutations, introduced into the strains by...

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Identifiers

PMID: 15522872
DOI: 10.1074/jbc.M411924200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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