Article
On the molecular basis of the thermal sensitivity of an Escherichia coli topA mutant.
The Journal of biological chemistry - 11 Jan 2002
Wang Yong, Lynch A Simon, Chen Sue-Jane, Wang James C
Abstract excerpt
Studies of two temperature-sensitive Escherichia coli topA strains AS17 and BR83, both of which were supposed to carry a topA amber mutation and a temperature-sensitive supD43,74 amber-suppressor, led to conflicting results regarding the essentiality of DNA topoisomerase I in cells grown in media of low osmolarity. We have therefore reexamined the molecular basis of the temperature sensitivity of strain AS17. We...
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