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Article

PriA is essential for viability of the Escherichia coli topoisomerase IV parE10(Ts) mutant.

Journal of bacteriology - 1 Feb 2004

Grompone Gianfranco, Bidnenko Vladimir, Ehrlich S Dusko, Michel Bénédicte

Abstract excerpt

The parE10(Ts) mutation, which renders Escherichia coli thermosensitive for growth by inactivation of the essential E. coli topoisomerase topo IV, is lethal at all temperatures when PriA, the main replication restart protein, is absent. This lethality is suppressed by the activation of a PriA-ind...

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Identifiers

PMID: 14762016
DOI: 10.1128/JB.186.4.1197-1199.2004
PMCID: PMC344234

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14762016-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

PriA is essential for viability of the Escherichia coli topoisomerase IV parE10(Ts) mutant.PMID 14762016Read ↗

Allele specific synthetic lethality between priC and dnaAts alleles at the permissive temperature of 30 degrees C in E. coli K-12.Semantic proximity Read ↗

Escherichia coli K-12 has two distinguishable PriA-PriB replication restart pathways.Semantic proximity Read ↗

Viability of Escherichia coli topA mutants lacking DNA topoisomerase I.Semantic proximity Read ↗

Escherichia coli PriA protein is essential for inducible and constitutive stable DNA replication.Semantic proximity Read ↗

Identification of dnaX as a high-copy suppressor of the conditional lethal and partition phenotypes of the parE10 allele.Semantic proximity Read ↗

A dnaT mutant with phenotypes similar to those of a priA2::kan mutant in Escherichia coli K-12.Semantic proximity Read ↗

Restart of DNA replication in Gram-positive bacteria: functional characterisation of the Bacillus subtilis PriA initiator.Semantic proximity Read ↗

Bacterial type 1A topoisomerases maintain the stability of the genome by preventing and dealing with R-loop-and nucleotide excision repair-dependent topological stressSemantic proximity Read ↗

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Multiple genetic pathways for restarting DNA replication forks in Escherichia coli K-12.Semantic proximity Read ↗

Mutations reducing replication from R-loops suppress the defects of growth, chromosome segregation and DNA supercoiling in cells lacking topoisomerase I and RNase HI activity.Semantic proximity Read ↗

Modulation of pPS10 host range by DnaA.Semantic proximity Read ↗

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