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Article

Multidrug-resistance 1 gene single-nucleotide polymorphisms do not influence long-term graft survival after kidney transplantation.

Transplantation proceedings - 1 Sept 2014

Saracino A, Muscaridola N, Cifarelli R A, Stallone G, Grandaliano G, Santarsia G

Abstract excerpt

BACKGROUND: The single-nucleotide polymorphisms (SNPs) of the Multidrug resistance 1 (MDR1) gene have been associated with changes in the pharmacokinetics of cyclosporine (CsA) and tacrolimus (FK506). Our aim was investigate the influence of MDR1 SNPs on long-term graft survival in a population of kidney transplant recipients. METHODS: We retrospectively analyzed 154 patients; they were genotyped for the SNPs...

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Identifiers

PMID: 25242754
DOI: 10.1016/j.transproceed.2014.07.051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Multidrug-resistance 1 gene single-nucleotide polymorphisms do not influence long-term graft survival after kidney transplantation.PMID 25242754Read ↗

CYP3A5 and CYP3A4 but not MDR1 single-nucleotide polymorphisms determine long-term tacrolimus disposition and drug-related nephrotoxicity in renal recipients.Semantic proximity Read ↗

Polymorphisms in CYP3A5, CYP3A4, and ABCB1 are not associated with cyclosporine pharmacokinetics nor with cyclosporine clinical end points after renal transplantation.Semantic proximity Read ↗

No association between single nucleotide polymorphisms and the development of nephrotoxicity after orthotopic heart transplantation.Semantic proximity Read ↗

ATP-binding cassette subfamily B member 1 polymorphisms do not determine cyclosporin exposure, acute rejection or nephrotoxicity after heart transplantation.Semantic proximity Read ↗

Multidrug resistant 1 (MDR1) C3435T and G2677T gene polymorphism: impact on the risk of acute rejection in pediatric kidney transplant recipients.Semantic proximity Read ↗

Genetic polymorphisms in CYP3A5 and MDR1 genes and their correlations with plasma levels of tacrolimus and cyclosporine in renal transplant recipients.Semantic proximity Read ↗

MDR1 C3435T polymorphisms correlate with cyclosporine levels in de novo renal recipients.Semantic proximity Read ↗

CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantationSemantic proximity Read ↗

Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic polymorphisms in the MDR-1, CYP3A4, and CYP3A5 genes.Semantic proximity Read ↗

The reduced function allele SLCO1B1 c.521T>C is of no practical relevance for the renal graft function over the first post-transplant year in patients treated with mycophenolic acid.Semantic proximity Read ↗

MDR1 haplotypes do not affect the steady-state pharmacokinetics of cyclosporine in renal transplant patients.Semantic proximity Read ↗

Multidrug resistance gene-1 (MDR-1) haplotypes have a minor influence on tacrolimus dose requirements.Semantic proximity Read ↗

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