Article
Association of the multidrug resistance-1 gene single-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients.
Journal of the American Society of Nephrology : JASN - 1 Jul 2003
Anglicheau Dany, Verstuyft Céline, Laurent-Puig Pierre, Becquemont Laurent, Schlageter Marie-Hélène, Cassinat Bruno, Beaune Philippe, Legendre Christophe, Thervet Eric
Abstract excerpt
The immunosuppressive drug tacrolimus, whose pharmacokinetic characteristics display large interindividual variations, is a substrate for P-glycoprotein (P-gp), the product of the multidrug resistance-1 (MDR1) gene. Some of the single nucleotide polymorphisms (SNP) of MDR1 reported correlated with the in vivo activity of P-gp. Because P-gp is known to control tacrolimus intestinal absorption, it was postulated...
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