Article
Association Between Tacrolimus Pharmacokinetics and Cytochrome P450 3A5 and Multidrug Resistance Protein 1 Exon 21 Polymorphisms.
Transplantation proceedings - 1 Jan 2000
Soda M, Fujitani M, Michiuchi R, Shibayama A, Kanamori K, Yoshikuni S, Ohno Y, Tsuchiya T, Suzuki A, Horie K, Deguchi T, Itoh Y, Kitaichi K
Abstract excerpt
BACKGROUND: Individual differences in the pharmacokinetics (PK) of tacrolimus (TAC), an immunosuppressive drug, are reportedly associated with single-nucleotide polymorphisms (SNPs) of cytochrome P450 (CYP) 3A5 and multidrug resistance protein 1 (MDR1). We determined the effect of SNPs in CYP3A5 and MDR1 exons 21 and 26 on TAC PK parameters. METHODS: Thirty-eight Japanese patients who underwent renal...
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