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Article

Overexpression of human DNA polymerase (Pol ) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate

28 Oct 2004

Abstract excerpt

DNA polymerase mu (Pol mu) is a DNA-dependent DNA polymerase closely related to terminal deoxynucleotidyl transferase (TdT), and prone to induce template/primer misalignments and misincorporation. In addition to a proposed general role in non-homologous end joining of double-strand breaks, its mutagenic potential and preferential expression in secondary lymphoid tissues support a role in somatic hypermutation...

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PMID: 15520469
DOI: 10.1093/nar/gkh929

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