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Article

DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells.

The EMBO journal - 3 Apr 2000

Domínguez O, Ruiz J F, Laín de Lera T, García-Díaz M, González M A, Kirchhoff T, Martínez-A C, Bernad A, Blanco L

Abstract excerpt

A novel DNA polymerase has been identified in human cells. Human DNA polymerase mu (Pol mu), consisting of 494 amino acids, has 41% identity to terminal deoxynucleotidyltransferase (TdT). Human Pol mu, overproduced in Escherichia coli in a soluble form and purified to homogeneity, displays intrinsic terminal deoxynucleotidyltransferase activity and a strong preference for activating Mn(2+) ions. Interestingly,...

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Identifiers

PMID: 10747040
DOI: 10.1093/emboj/19.7.1731
PMCID: PMC310241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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