Article
Somatic D-loop mitochondrial DNA mutations are frequent in uterine serous carcinoma.
European journal of cancer (Oxford, England : 1990) - 1 Nov 2004
Pejovic Tanja, Ladner Daniela, Intengan Marilyn, Zheng Karl, Fairchild Tracy, Dillon Deborah, Easley Samantha, Dillon Dionne, Marchetti David, Schwartz Peter, Lele Shashikant, Costa Jose, Odunsi Kunle
Abstract excerpt
The mitochondria plays a role in apoptosis. Its genome is also more susceptible to mutations because of high levels of reactive oxygen species and limited repair mechanisms. The D-loop of mitochondrial DNA (mtDNA) contains essential transcription and replication elements, and mutations in this re...
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