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Detection of somatic mutations and germline polymorphisms in mitochondrial DNA of uterine fibroids patients.

Genetic testing and molecular biomarkers - 1 Jan 2000

Shaik Noor Ahmad, Lone Waseem Gul, Khan Imran Ali, Vaidya Sireesha, Rao Kaipa Prabhakar, Kodati Vijaya Lakshmi, Hasan Qurratulain

Abstract excerpt

To identify the role of mitochondrial DNA (mtDNA) mutations in uterine fibroids patients, genomic DNA isolated from paired myometrium and fibroid tissues was screened for mutations. The present study represents the first investigation to report that 10.4% of uterine fibroids cases had either mtDNA mutations or polymorphisms or both. Among the 14 mitochondrial sequence variants identified, seven are somatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21453057
DOI: 10.1089/gtmb.2010.0255

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