Article
High frequency of mitochondrial genome instability in human endometrial carcinomas.
British journal of cancer - 18 Aug 2003
Liu V W S, Yang H J, Wang Y, Tsang P C K, Cheung A N Y, Chiu P M, Ng T Y, Wong L C, Nagley P, Ngan H Y S
Abstract excerpt
To investigate the occurrence of somatic mitochondrial DNA (mtDNA) mutations in human primary endometrial carcinomas, we sequenced the D-loop region, the 12S and 16S rRNA genes of mtDNA of cancer tissues and their matched normal controls. About 56% (28 out of 50) of cases carry one or more somatic changes in mtDNA including deletion, point mutation and mitochondrial microsatellite instability (mtMSI), namely the...
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