Article
Mutation spectrum and sequence alkylation selectivity resulting from modification of bacteriophage M13mp18 DNA with S-(2-chloroethyl)glutathione. Evidence for a role of S-(2-N7-guanyl)ethyl)glutathione as a mutagenic lesion formed from ethylene dibromide.
The Journal of biological chemistry - 5 Apr 1992
Cmarik J L, Humphreys W G, Bruner K L, Lloyd R S, Tibbetts C, Guengerich F P
Abstract excerpt
The major DNA adduct (greater than 95% total) resulting from the bioactivation of ethylene dibromide by conjugation with GSH is S-(2-(N7-guanyl)ethyl)GSH. The mutagenic potential of this adduct has been uncertain, however, because the observed mutagenicity might be caused by other adducts present...
Topics
- Alkylation
- Bacteriophages
- Base Sequence
- DNA Adducts
- DNA, Viral
- Ethylene Dibromide
- Genes, Viral
- Glutathione
- Molecular Sequence Data
- Mutation