The role of human O(6)-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli.

doi:10.1016/s0027-5107(00)00062-2

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Article

The role of human O(6)-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli.

Mutation research - 20 Jul 2000

Liu H, Xu-Welliver M, Pegg A E

Abstract excerpt

The expression of the DNA repair protein human O(6)-alkylguanine-DNA alkyltransferase (AGT) in Escherichia coli strains GWR109 or TRG8 that lack endogenous AGT greatly increased the toxicity and mutagenicity of 1,2-dibromoethane (DBE). Pretreatment of strain TRG8 expressing human AGT, which is permeable to exogenous drugs, with the AGT inhibitor O(6)-benzylguanine (BG) abolished the lethal and mutagenic effects...

Topics

DNA, Recombinant
Dose-Response Relationship, Drug
Escherichia coli
Ethylene Dibromide
Humans
Mutagenicity Tests
Mutation
O(6)-Methylguanine-DNA Methyltransferase
Plasmids
Transformation, Genetic

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PMID: 10894884
DOI: 10.1016/s0027-5107(00)00062-2

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