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Article

A novel high-specificity approach for colorectal neoplasia: Detection of K-ras2 oncogene mutation in normal mucosa.

International journal of cancer - 1 Mar 2005

Yamada Shinobu, Yashiro Masakazu, Maeda Kiyoshi, Nishiguchi Yukio, Hirakawa Kosei

Abstract excerpt

There is an important need for a high-specificity approach to colorectal cancer. Approximately 50% of colorectal tumors contain K-ras gene mutations, which occur as an early step in carcinogenesis. K-ras mutations were detectable not only in tumors but also in microscopically normal colorectal mu...

Topics

Colon
Colorectal Neoplasms
DNA Primers
Humans
Intestinal Mucosa
Mutation
Neoplasm Staging
Polymerase Chain Reaction
Proto-Oncogene Proteins
Proto-Oncogene Proteins p21(ras)
Reference Values

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

ras Proteins

Source

Identifiers

PMID: 15514939
DOI: 10.1002/ijc.20666

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-15514939-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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A novel high-specificity approach for colorectal neoplasia: Detection of K-ras2 oncogene mutation in normal mucosa.PMID 15514939Read ↗

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