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Article

A novel high-specificity approach for colorectal neoplasia: Detection of K-ras2 oncogene mutation in normal mucosa.

International journal of cancer - 1 Mar 2005

Yamada Shinobu, Yashiro Masakazu, Maeda Kiyoshi, Nishiguchi Yukio, Hirakawa Kosei

Abstract excerpt

There is an important need for a high-specificity approach to colorectal cancer. Approximately 50% of colorectal tumors contain K-ras gene mutations, which occur as an early step in carcinogenesis. K-ras mutations were detectable not only in tumors but also in microscopically normal colorectal mucosa close to carcinomas in some patients with colorectal cancer. This is the first systematic analysis of K-ras...

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Identifiers

PMID: 15514939
DOI: 10.1002/ijc.20666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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