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Article

Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinomas.

Journal of the National Cancer Institute - 7 Jul 1993

Shibata D, Schaeffer J, Li Z H, Capella G, Perucho M

Abstract excerpt

BACKGROUND: Previous molecular genetics studies of colorectal cancer have identified multiple mutations in the c-K-ras gene (also known as KRAS2) in all phases of its development. Because of technical difficulty, prior studies rarely focused attention on the detailed distribution of c-K-ras mutat...

Topics

Adenocarcinoma
Adenoma
Colorectal Neoplasms
DNA, Neoplasm
Gene Expression Regulation, Neoplastic
Genes, p53
Genes, ras
Humans
Mutation
Polymerase Chain Reaction
Ultraviolet Rays

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8515492
DOI: 10.1093/jnci/85.13.1058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8515492-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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