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Article

Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.

Nature - 5 Jul 2001

Dann C E, Hsieh J C, Rattner A, Sharma D, Nathans J, Leahy D J

Abstract excerpt

Members of the Frizzled family of seven-pass transmembrane proteins serve as receptors for Wnt signalling proteins. Wnt proteins have important roles in the differentiation and patterning of diverse tissues during animal development, and inappropriate activation of Wnt signalling pathways is a key feature of many cancers. An extracellular cysteine-rich domain (CRD) at the amino terminus of Frizzled proteins binds...

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PMID: 11452312
DOI: 10.1038/35083601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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