Article
Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.
Molecular and cellular biology - 1 Nov 2004
Martins L Miguel, Morrison Alastair, Klupsch Kristina, Fedele Valentina, Moisoi Nicoleta, Teismann Peter, Abuin Alejandro, Grau Evelyn, Geppert Martin, Livi George P, Creasy Caretha L, Martin Alison, Hargreaves Iain, Heales Simon J, Okada Hitoshi, Brandner Sebastian, Schulz Jörg B, Mak Tak, Downward Julian
Abstract excerpt
The serine protease HtrA2/Omi is released from the mitochondrial intermembrane space following apoptotic stimuli. Once in the cytosol, HtrA2/Omi has been implicated in promoting cell death by binding to inhibitor of apoptosis proteins (IAPs) via its amino-terminal Reaper-related motif, thus inducing caspase activity, and also in mediating caspase-independent death through its own protease activity. We report here...
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