Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-B.

Nature cell biology - 1 Jul 2000

Katagiri Y, Takeda K, Yu Z X, Ferrans V J, Ozato K, Guroff G

Abstract excerpt

The retinoid-X receptor (RXR) regulates multiple hormonal pathways through heterodimerization with nuclear receptors such as the all-trans retinoic acid receptor (RAR). The orphan nuclear receptor NGFI-B (also called Nur77) can heterodimerize with RXR. Here we show that nerve growth factor (NGF) induces the phosphorylation of Ser 105 of NGFI-B in PC12 phaeochromocytoma cells, resulting in translocation of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nerve Growth Factor
Share to Nuclear Localization Signals
Share to Phosphoserine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptor Cross-Talk

Share to Receptors, Retinoic Acid

Share to Receptors, Steroid

Share to Retinoid X Receptors

Share to Retinoids

Source

Identifiers

PMID: 10878809
DOI: 10.1038/35017072

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-B.PMID 10878809Read ↗

Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting.Semantic proximity Read ↗

Adapter protein SH2-B beta undergoes nucleocytoplasmic shuttling: implications for nerve growth factor induction of neuronal differentiation.Semantic proximity Read ↗

Regulation of NGFI‐B/Nur77 gene expression in the rat ovary and in leydig tumor cells MA‐10Semantic proximity Read ↗

Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells.Semantic proximity Read ↗

Structural basis for the cell-specific activities of the NGFI-B and the Nurr1 ligand-binding domain.Semantic proximity Read ↗

Constitutive overexpression of the basic helix-loop-helix Nex1/MATH-2 transcription factor promotes neuronal differentiation of PC12 cells and neurite regeneration.Semantic proximity Read ↗

Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor.Semantic proximity Read ↗

PC12nnr5 cells expressing TrkA receptors undergo morphological but not cholinergic phenotypic differentiation in response to nerve growth factor.Semantic proximity Read ↗

The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production.Semantic proximity Read ↗

Leukemia inhibitory factor receptor signaling negatively modulates nerve growth factor-induced neurite outgrowth in PC12 cells and sympathetic neurons.Semantic proximity Read ↗

The NGFI-B family of transcription factors regulates expression of 3beta-hydroxysteroid dehydrogenase type 2 in the human ovary.Semantic proximity Read ↗

Sustained activation of phosphatidylinositol 3-kinase/Akt/nuclear factor kappaB signaling mediates G protein-coupled delta-opioid receptor gene expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.