Article
Quantitative fish determination of chromosome 3 arm imbalances in lung tumors by automated image cytometry.
Medical science monitor : international medical journal of experimental and clinical research - 1 Nov 2004
Truong Khuong, Gibaud Anne, Zalcman Gérard, Guilly Marie Noëlle, Antoine Martine, Commo Frédéric, Fouquet Coralie, Cadranel Jacques, Soussi Thierry, Dutrillaux Bernard, Malfoy Bernard
Abstract excerpt
BACKGROUND: Clonal heterogeneity is a major difficulty in the analysis of chromosome rearrangements within tumor tissue. Using in situ hybridization, a cell-to-cell analysis can be performed and should allow a better understanding of the genetic process. In addition, detection of pre-neoplastic lesions with only a few cells involved may improve the diagnosis of such lesions and their precocious treatment....
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