Article
Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer.
American journal of respiratory and critical care medicine - 1 Jul 2010
McCaughan Frank, Pole Jessica C M, Bankier Alan T, Konfortov Bernard A, Carroll Bernadette, Falzon Mary, Rabbitts Terence H, George P Jeremy, Dear Paul H, Rabbitts Pamela H
Abstract excerpt
RATIONALE: Amplification of distal 3q is the most common genomic aberration in squamous lung cancer (SQC). SQC develops in a multistage progression from normal bronchial epithelium through dysplasia to invasive disease. Identifying the key driver events in the early pathogenesis of SQC will facilitate the search for predictive molecular biomarkers and the identification of novel molecular targets for...
Topics
- Aged
- Bronchial Neoplasms
- Chromosomes, Human, Pair 3
- Female
- Gene Amplification
- Humans
- Male
- Middle Aged
- Mutation
- Neoplasm Invasiveness
- Neoplasms, Squamous Cell