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Article

Mapping of multiple DNA gains and losses in primary small cell lung carcinomas by comparative genomic hybridization.

Cancer research - 1 Apr 1994

Ried T, Petersen I, Holtgreve-Grez H, Speicher M R, Schröck E, du Manoir S, Cremer T

Abstract excerpt

Comparative genomic hybridization was applied for a comprehensive screening of under- and overrepresentation of genetic material in 13 autoptic small cell lung cancer specimens. The most abundant genetic changes include DNA losses of chromosome arms 3p, 5q, 10q, 13q, and 17p and DNA gains of 3q, 5p, 8q, and 17q. Amplification sites in these tumors were mapped to 22 chromosome bands. The most frequently involved...

Topics

Autopsy
Carcinoma, Small Cell
Chromosome Banding
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human
DNA, Neoplasm
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphatic Metastasis

Mutation

Neoplasm Metastasis

Source

Identifiers

PMID: 8137295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8137295-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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