Article
Demonstration that mast cells, T cells, and B cells bearing the activating kit mutation D816V occur in clusters within the marrow of patients with mastocytosis.
The Journal of molecular diagnostics : JMD - 1 Nov 2004
Taylor Marcia L, Sehgal Devinder, Raffeld Mark, Obiakor Harold, Akin Cem, Mage Rose G, Metcalfe Dean D
Abstract excerpt
Mastocytosis is characterized by focal heterotypic clusters of mast cells and lymphocytes in the bone marrow and by a somatically acquired activating Kit mutation, D816V. The relationship of the occurrence of this mutation to the heterotypic clusters of mast cells and lymphocytes in bone marrow is unknown. We hypothesized that these two unique features of mastocytosis were related. To explore this hypothesis,...
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