Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chronically KIT-stimulated clonally-derived human mast cells show heterogeneity in different tissue microenvironments.

The Journal of investigative dermatology - 1 May 1997

Longley B J, Tyrrell L, Lu S, Ma Y, Klump V, Murphy G F

Abstract excerpt

Human mast cell precursors arise in the bone marrow and circulate to different tissue microenvironments, where they develop distinct phenotypes that may be characterized by differential expression of the serine protease, chymase. The growth and development of mast cells is stimulated by mast cell growth factor, which is also known as kit ligand because its obligate receptor is KIT, the protein product of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clone Cells
Share to Genetic Heterogeneity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Point Mutation

Share to Proto-Oncogene Mas

Share to Serine Endopeptidases

Share to Spleen

Source

Identifiers

PMID: 9129234
DOI: 10.1111/1523-1747.ep12292240

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chronically KIT-stimulated clonally-derived human mast cells show heterogeneity in different tissue microenvironments.PMID 9129234Read ↗

Clonality and molecular pathogenesis of mastocytosis.Semantic proximity Read ↗

Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm.Semantic proximity Read ↗

Decoding the intricacies of the mast cell compartment.Semantic proximity Read ↗

Phenotypic heterogeneity, novel diagnostic markers, and target expression profiles in normal and neoplastic human mast cells.Semantic proximity Read ↗

Mastocytosis: recent advances in defining the disease.Semantic proximity Read ↗

Mastocytosis.Semantic proximity Read ↗

Urticaria pigmentosa.Semantic proximity Read ↗

Demonstration that mast cells, T cells, and B cells bearing the activating kit mutation D816V occur in clusters within the marrow of patients with mastocytosis.Semantic proximity Read ↗

Is it time for a new classification of mast cells? What do we know about mast cell heterogeneity?Semantic proximity Read ↗

Advances in mast cell biology: new understanding of heterogeneity and functionSemantic proximity Read ↗

Increased group 2 innate lymphoid cells in peripheral blood of adults with mastocytosis.Semantic proximity Read ↗

Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.