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Article

KIT D816V mutation-positive cell fractions in lesional skin biopsies from adults with systemic mastocytosis.

Dermatology (Basel, Switzerland) - 1 Jan 2013

Kristensen Thomas, Broesby-Olsen Sigurd, Vestergaard Hanne, Bindslev-Jensen Carsten, Møller Michael Boe

Abstract excerpt

BACKGROUND: Most adults with systemic mastocytosis (SM) carry the somatic KIT D816V mutation, but the occurrence of the mutation in lesional skin remains to be characterized. OBJECTIVE: To assess the distribution and fraction of KIT D816V mutation-positive cells in lesional skin. METHODS: Lesional skin biopsies from 29 adults with SM were analysed using sensitive and quantitative qPCR KIT D816V mutation analysis....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23774045
DOI: 10.1159/000349986

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KIT

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