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Article

High frequency of concomitant mastocytosis in patients with acute myeloid leukemia exhibiting the transforming KIT mutation D816V.

Molecular oncology - 1 Aug 2010

Fritsche-Polanz Robert, Fritz Marika, Huber Andrea, Sotlar Karl, Sperr Wolfgang R, Mannhalter Christine, Födinger Manuela, Valent Peter

Abstract excerpt

The KIT mutation D816V is associated with autonomous growth of mast cells (MC) and is detectable in most patients with systemic mastocytosis (SM), including cases with associated hematologic non-MC-lineage disease (AHNMD). Recently, KIT D816V was reported to be expressed in patients with acute myeloid leukemia (AML). However, it was not clarified whether these patients have co-existing occult SM. We investigated...

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Topics

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Share to Kaplan-Meier Estimate
Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mast Cells

Share to Mastocytosis, Systemic

Share to Polymorphism, Restriction Fragment Length

Share to Proto-Oncogene Proteins c-kit

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Source

Open in PubMed Open full text

Identifiers

PMID: 20471335
DOI: 10.1016/j.molonc.2010.04.008
PMCID: PMC5527910

Genes

KIT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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High frequency of concomitant mastocytosis in patients with acute myeloid leukemia exhibiting the transforming KIT mutation D816V.PMID 20471335Read ↗

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Molecular profiling of myeloid progenitor cells in multi-mutated advanced systemic mastocytosis identifies KIT D816V as a distinct and late event.Semantic proximity Read ↗

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