Article
Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm.
Nature genetics - 1 Mar 1996
Longley B J, Tyrrell L, Lu S Z, Ma Y S, Langley K, Ding T G, Duffy T, Jacobs P, Tang L H, Modlin I
Abstract excerpt
Mastocytosis is characterized by accumulations of mast cells in various organs (1). Most cases are indolent and confined to the skin, where discrete mast cell infiltrates are associated increased epidermal melanin, a clinical picture known as urticaria pigmentosa (UP). Other forms of mastocytosis...
Topics
- Adult
- Base Sequence
- Clone Cells
- DNA Primers
- Humans
- Immunoenzyme Techniques
- Male
- Mast Cells
- Mastocytosis
- Molecular Sequence Data
- Mutation
- Neoplasms, Connective Tissue
- Proto-Oncogene Mas
- Proto-Oncogene Proteins c-kit
- Splenic Diseases
- Urticaria Pigmentosa