Article
In aggressive forms of mastocytosis, TET2 loss cooperates with c-KITD816V to transform mast cells.
Blood - 6 Dec 2012
Soucie Erinn, Hanssens Katia, Mercher Thomas, Georgin-Lavialle Sophie, Damaj Gandhi, Livideanu Cristina, Chandesris Maria Olivia, Acin Yolène, Létard Sebastien, de Sepulveda Paulo, Hermine Olivier, Bernard Olivier A, Dubreuil Patrice
Abstract excerpt
Although a role for oncogenic KIT in driving mast cell disease is clear, the mechanisms driving the multiple phenotypic and clinical manifestations of this disorder are not well elucidated. We now show, using a large cohort of mastocytosis patients, including an almost equal number of aggressive and nonaggressive cases of systemic mastocytosis, that in contrast to the oncogenic KITD816V, TET2 mutation...
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