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Article

Sumoylation of MITF and its related family members TFE3 and TFEB.

The Journal of biological chemistry - 7 Jan 2005

Miller Arlo J, Levy Carmit, Davis Ian J, Razin Ehud, Fisher David E

Abstract excerpt

MITF and its related family members TFE3 and TFEB heterodimerize with each other, recognize the same DNA sequences, and are subject to many of the same post-translational modifications. We show that lysine residues within conserved small ubiquitin-like modifier (SUMO) consensus sites in these family members are subject to SUMO modification. Mutation of these sites significantly affects the transcriptional...

Read the complete abstract on PubMed

Topics

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Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to Binding Sites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Lysine

Share to Microphthalmia-Associated Transcription Factor

Share to Neoplasm Proteins

Share to Protein Processing, Post-Translational

Share to SUMO-1 Protein

Source

Identifiers

PMID: 15507434
DOI: 10.1074/jbc.M411757200

Genes

MITF
TFEB
TRPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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