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Article

microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family.

Genes & development - 15 Nov 1994

Hemesath T J, Steingrímsson E, McGill G, Hansen M J, Vaught J, Hodgkinson C A, Arnheiter H, Copeland N G, Jenkins N A, Fisher D E

Abstract excerpt

The microphthalmia (mi) gene appears essential for pigment cell development and/or survival, based on its mutation in mi mice. It has also been linked to the human disorder Waardenburg Syndrome. The mi gene was recently cloned and predicts a basic/helix-loop-helix/leucine zipper (b-HLH-ZIP) factor with tissue-restricted expression. Here, we show that Mi protein binds DNA as a homo- or heterodimer with TFEB, TFE3,...

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Source

Identifiers

PMID: 7958932
DOI: 10.1101/gad.8.22.2770

Genes

TFEB
TFEC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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