Article
microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family.
Genes & development - 15 Nov 1994
Hemesath T J, Steingrímsson E, McGill G, Hansen M J, Vaught J, Hodgkinson C A, Arnheiter H, Copeland N G, Jenkins N A, Fisher D E
Abstract excerpt
The microphthalmia (mi) gene appears essential for pigment cell development and/or survival, based on its mutation in mi mice. It has also been linked to the human disorder Waardenburg Syndrome. The mi gene was recently cloned and predicts a basic/helix-loop-helix/leucine zipper (b-HLH-ZIP) facto...
Topics
- Alternative Splicing
- Animals
- Base Sequence
- DNA-Binding Proteins
- Gene Expression Regulation
- Genes, Reporter
- Melanocytes
- Mice
- Microphthalmia-Associated Transcription Factor
- Molecular Sequence Data
- Mutation
- Transcription Factors