Article

Novel mechanisms of MITF regulation and melanoma predisposition identified in a mouse suppressor screen

2023-08-04

Abstract excerpt

MITF, a basic-Helix-Loop-Helix Zipper (bHLHZip) transcription factor, plays vital roles in melanocyte development and functions as an oncogene. To explore MITF regulation and its role in melanoma, we conducted a genetic screen for suppressors of the Mitf-associated pigmentation phenotype. An intragenic Mitf mutation was identified, leading to termination of MITF at the K316 SUMOylation site and loss of the C-end i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3c3e76ad-fe2b-5f47-a57c-8a938820054b
DOI: 10.1101/2023.08.04.551952

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel mechanisms of MITF regulation and melanoma predisposition identified in a mouse suppressor screenDOI 10.1101/2023.08.04.551952Read

Novel mechanisms of MITF regulation identified in a mouse suppressor screen.Semantic proximity Read

MITF, the Janus transcription factor of melanoma.Semantic proximity Read

A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma.Semantic proximity Read

MITF mutations associated with pigment deficiency syndromes and melanoma have different effects on protein function.Semantic proximity Read

A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma.Semantic proximity Read

Deciphering the Role of Oncogenic MITFE318K in Senescence Delay and Melanoma ProgressionSemantic proximity Read

Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF.Semantic proximity Read

MITF: master regulator of melanocyte development and melanoma oncogene.Semantic proximity Read

Beyond MITF: Multiple transcription factors directly regulate the cellular phenotype in melanocytes and melanoma.Semantic proximity Read

The small MAF transcription factor MAFG co-opts MITF to promote melanoma progressionSemantic proximity Read

A germline oncogenic MITF mutation and tumor susceptibility.Semantic proximity Read

A MAFG~MITF complex drives melanoma phenotype switching and progression.Semantic proximity Read