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Article

Expression and characterization of SUMO-conjugated metal-responsive transcription factor 1: SIM-dependent cross-interaction and distinct DNA binding activity.

Journal of biochemistry - 1 Apr 2013

Lin Chang-Yi, Liu Ya-Chuan, Lin Meng-Chieh, Thi Nguyen Thao, Tam Ming F, Chein Chih-Yuan, Lin Meng-Ting, Lin Lih-Yuan

Abstract excerpt

Metal-responsive transcription factor 1 (MTF-1) regulates a variety of genes involving in metal homeostasis and oxidative stress. We have shown that MTF-1 can be conjugated by small ubiquitin-like modifier (SUMO) and forms complexes with cellular factor(s) in a SUMO-interacting motif (SIM)-dependent manner. To investigate whether the interaction of MTF-1 and its SUMO conjugate occurs, we expressed and isolated...

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PMID: 23347955
DOI: 10.1093/jb/mvt002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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