Article
Novel mechanisms of MITF regulation identified in a mouse suppressor screen.
EMBO reports - 1 Oct 2024
Vu Hong Nhung, Valdimarsson Matti Már, Sigurbjörnsdóttir Sara, Bergsteinsdóttir Kristín, Debbache Julien, Bismuth Keren, Swing Deborah A, Hallsson Jón H, Larue Lionel, Arnheiter Heinz, Copeland Neal G, Jenkins Nancy A, Heidarsson Petur O, Steingrímsson Eiríkur
Abstract excerpt
MITF, a basic Helix-Loop-Helix Zipper (bHLHZip) transcription factor, plays vital roles in melanocyte development and functions as an oncogene. We perform a genetic screen for suppressors of the Mitf-associated pigmentation phenotype in mice and identify an intragenic Mitf mutation that terminates MITF at the K316 SUMOylation site, leading to loss of the C-end intrinsically disordered region (IDR). The resulting...
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