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Article

The adenovirus E4orf6 protein inhibits DNA double strand break repair and radiosensitizes human tumor cells in an E1B-55K-independent manner.

The Journal of biological chemistry - 14 Jan 2005

Hart Lori S, Yannone Steven M, Naczki Christine, Orlando Joseph S, Waters Stephen B, Akman Steven A, Chen David J, Ornelles David, Koumenis Constantinos

Abstract excerpt

The adenoviral protein E4orf6 has been shown to inhibit both in vitro V(D)J recombination and adenoviral DNA concatenation, two processes that rely on cellular DNA double strand break repair (DSBR) proteins. Most of the known activities of E4orf6 during adenoviral infection require its interaction with another adenoviral protein, E1B-55K. Here we report that E4orf6, stably expressed in RKO human colorectal...

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PMID: 15507430
DOI: 10.1074/jbc.M409934200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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