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Article

End-joining deficiency and radiosensitization induced by gemcitabine.

Cancer research - 15 Feb 2001

van Putten JWG, Groen HJM, Smid K, Peters G J, Kampinga H H

Abstract excerpt

The mechanism of radiosensitization by gemcitabine (2',2'-difluoro-2'-deoxycytidine, dFdC) is not exactly known. We investigated the possible role of inhibition of the repair of DNA double-strand breaks by dFdC by measuring the extent of radiosensitization in different cell lines deficient and proficient in components of nonhomologous end-joining and in the parental cell lines. Different cell lines were incubated...

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Identifiers

PMID: 11245469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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