Article
The role of TFIID, the initiator element and a novel 5' TFIID binding site in the transcriptional control of the TATA-less human cytosolic phospholipase A2-alpha promoter.
Biochimica et biophysica acta - 5 Nov 2004
Cowan Mark J, Yao Xiang-Lan, Pawliczak Rafal, Huang Xiuli, Logun Carolea, Madara Patricia, Alsaaty Sura, Wu Tong, Shelhamer James H
Abstract excerpt
Human cytosolic phospholipase A2-alpha (cPLA2-alpha) is a critical enzyme in the liberation of arachidonic acid (AA) from cellular membranes and the subsequent formation of prostaglandins (PGs), leukotrienes (LTs), hydroxyeicosatetraenoic acids (HETEs) and platelet activating factor in many different cell types. Much is known of the effect of posttranslational phosphorylation and calcium binding events on the...
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