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Article

The human initiator is a distinct and abundant element that is precisely positioned in focused core promoters.

Genes & development - 1 Jan 2017

Vo Ngoc Long, Cassidy California Jack, Huang Cassidy Yunjing, Duttke Sascha H C, Kadonaga James T

Abstract excerpt

DNA sequence signals in the core promoter, such as the initiator (Inr), direct transcription initiation by RNA polymerase II. Here we show that the human Inr has the consensus of BBCA+1BW at focused promoters in which transcription initiates at a single site or a narrow cluster of sites. The analysis of 7678 focused transcription start sites revealed 40% with a perfect match to the Inr and 16% with a single...

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Identifiers

PMID: 28108474
DOI: 10.1101/gad.293837.116
PMCID: PMC5287114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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