Article
Genome-wide detection of a TFIID localization element from an initial human disease mutation.
Nucleic acids research - 1 Mar 2011
Yang Mary Q, Laflamme Karina, Gotea Valer, Joiner Clinton H, Seidel Nancy E, Wong Clara, Petrykowska Hanna M, Lichtenberg Jens, Lee Stephen, Welch Lonnie, Gallagher Patrick G, Bodine David M, Elnitski Laura
Abstract excerpt
Eukaryotic core promoters are often characterized by the presence of consensus motifs such as the TATA box or initiator elements, which attract and direct the transcriptional machinery to the transcription start site. However, many human promoters have none of the known core promoter motifs, suggesting that undiscovered promoter motifs exist in the genome. We previously identified a mutation in the human...
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