Article
CLC-2 single nucleotide polymorphisms (SNPs) as potential modifiers of cystic fibrosis disease severity.
BMC medical genetics - 26 Oct 2004
Blaisdell Carol J, Howard Timothy D, Stern Augustus, Bamford Penelope, Bleecker Eugene R, Stine O Colin
Abstract excerpt
BACKGROUND: Cystic fibrosis (CF) lung disease manifest by impaired chloride secretion leads to eventual respiratory failure. Candidate genes that may modify CF lung disease severity include alternative chloride channels. The objectives of this study are to identify single nucleotide polymorphisms (SNPs) in the airway epithelial chloride channel, CLC-2, and correlate these polymorphisms with CF lung disease....
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